|Title||Withdrawal of corticosteroids in inflammatory bowel disease patients after dependency periods ranging from 2 to 45 years: a proposed method.|
|Publication Type||Journal Article|
|Year of Publication||2009|
|Authors||Murphy SJ, Wang L, Anderson LA, Steinlauf A, Present DH, Mechanick JI|
|Journal||Aliment Pharmacol Ther|
|Date Published||2009 Nov 15|
|Keywords||Adrenal Cortex Hormones, Adult, Aged, Dexamethasone, Female, Humans, Inflammatory Bowel Diseases, Male, Middle Aged, Retrospective Studies, Substance Withdrawal Syndrome, Substance-Related Disorders, Time Factors, Treatment Outcome|
BACKGROUND: Even in the biologic era, corticosteroid dependency in IBD patients is common and causes a lot of morbidity, but methods of withdrawal are not well described.
AIM: To assess the effectiveness of a corticosteroid withdrawal method.
METHODS: Twelve patients (10 men, 2 women; 6 ulcerative colitis, 6 Crohn's disease), median age 53.5 years (range 29-75) were included. IBD patients with quiescent disease refractory to conventional weaning were transitioned to oral dexamethasone, educated about symptoms of the corticosteroid withdrawal syndrome (CWS) and weaned under the supervision of an endocrinologist. When patients failed to wean despite a slow weaning pace and their IBD remaining quiescent, low dose synthetic ACTH stimulation testing was performed to assess for adrenal insufficiency. Multivariate analysis was performed to assess predictors of a slow wean.
RESULTS: Median durations for disease and corticosteroid dependency were 21 (range 3-45) and 14 (range 2-45) years respectively. Ten patients (83%) were successfully weaned after a median follow-up from final wean of 38 months (range 5-73). Disease flares occurred in two patients, CWS in five and ACTH testing was performed in 10. Multivariate analysis showed that longer duration of corticosteroid use appeared to be associated with a slower wean (P = 0.056).
CONCLUSIONS: Corticosteroid withdrawal using this protocol had a high success rate and durable effect and was effective in patients with long-standing (up to 45 years) dependency. As symptoms of CWS mimic symptoms of IBD disease flares, gastroenterologists may have difficulty distinguishing them, which may be a contributory factor to the frequency of corticosteroid dependency in IBD patients.
|Alternate Journal||Aliment. Pharmacol. Ther.|