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Regulation of inflammation by microbiota interactions with the host.

TitleRegulation of inflammation by microbiota interactions with the host.
Publication TypeJournal Article
Year of Publication2017
AuthorsJ Blander M, Longman RS, Iliev ID, Sonnenberg GF, Artis D
JournalNat Immunol
Volume18
Issue8
Pagination851-860
Date Published2017 Jul 19
ISSN1529-2916
KeywordsAdaptive Immunity, Antigen-Presenting Cells, Autoimmune Diseases, Gastrointestinal Microbiome, Humans, Immunity, Innate, Immunity, Mucosal, Infection, Inflammation, Lymphocytes, Neoplasms, Neurodegenerative Diseases, Symbiosis, T-Lymphocytes, Regulatory, Vaccination
Abstract

The study of the intestinal microbiota has begun to shift from cataloging individual members of the commensal community to understanding their contributions to the physiology of the host organism in health and disease. Here, we review the effects of the microbiome on innate and adaptive immunological players from epithelial cells and antigen-presenting cells to innate lymphoid cells and regulatory T cells. We discuss recent studies that have identified diverse microbiota-derived bioactive molecules and their effects on inflammation within the intestine and distally at sites as anatomically remote as the brain. Finally, we highlight new insights into how the microbiome influences the host response to infection, vaccination and cancer, as well as susceptibility to autoimmune and neurodegenerative disorders.

DOI10.1038/ni.3780
Alternate JournalNat. Immunol.
PubMed ID28722709
PubMed Central IDPMC5800875
Grant ListR01 AI074878 / AI / NIAID NIH HHS / United States
R21 DK110262 / DK / NIDDK NIH HHS / United States
R21 CA201829 / CA / NCI NIH HHS / United States
R00 DK098310 / DK / NIDDK NIH HHS / United States
R01 AI095466 / AI / NIAID NIH HHS / United States
R01 DK111862 / DK / NIDDK NIH HHS / United States
R21 AI123819 / AI / NIAID NIH HHS / United States
R01 AI123368 / AI / NIAID NIH HHS / United States
DP5 OD012116 / OD / NIH HHS / United States
R01 AI127658 / AI / NIAID NIH HHS / United States
P01 DK072201 / DK / NIDDK NIH HHS / United States
R01 AI102942 / AI / NIAID NIH HHS / United States
R01 AI073899 / AI / NIAID NIH HHS / United States
K08 DK099381 / DK / NIDDK NIH HHS / United States
R21 AI087990 / AI / NIAID NIH HHS / United States
K99 DK098310 / DK / NIDDK NIH HHS / United States
R01 AI095245 / AI / NIAID NIH HHS / United States
R21 AI083480 / AI / NIAID NIH HHS / United States
U01 AI095608 / AI / NIAID NIH HHS / United States
R01 AI061570 / AI / NIAID NIH HHS / United States
R01 AI097333 / AI / NIAID NIH HHS / United States
R56 AI073899 / AI / NIAID NIH HHS / United States
R01 AI123284 / AI / NIAID NIH HHS / United States