Peripheral neuropathic symptoms in celiac disease and inflammatory bowel disease.

TitlePeripheral neuropathic symptoms in celiac disease and inflammatory bowel disease.
Publication TypeJournal Article
Year of Publication2012
AuthorsShen T-CDavid, Lebwohl B, Verma H, Kumta N, Tennyson C, Lewis S, Scherl E, Swaminath A, Capiak KM, DiGiacomo D, Bosworth BP, Brannagan TH, Green PHR
JournalJ Clin Neuromuscul Dis
Date Published2012 Mar
KeywordsAdult, Celiac Disease, Female, Humans, Inflammatory Bowel Diseases, Logistic Models, Male, Middle Aged, Peripheral Nervous System Diseases, Questionnaires, Restless Legs Syndrome, Retrospective Studies, Severity of Illness Index, Vitamins, Young Adult

OBJECTIVES: An association between celiac disease (CD) and peripheral neuropathy (PN) has been reported.

METHODS: Patients with CD and/or inflammatory bowel disease (IBD) were recruited from the gastroenterology clinics at a medical center and local support groups. Control subjects without CD or IBD were recruited from the staff of the medical center as well as relatives and attendees at support groups. Each participant completed a survey that used two validated PN instruments to define and characterize PN.

RESULTS: In the CD group, 38.9% met criteria for PN compared with 38.7% in the IBD group (P = 0.97) and 20.5% in the control group (P < 0.001). On multiple logistic regression, the odds of PN after adjusting for age, gender, diabetes, vitamin B12 deficiency, and cancer history were increased for CD (odds ratio, 2.51; 95% confidence interval, 1.82-3.47) and IBD (odds ratio, 2.78; 95% confidence interval, 1.85-4.18).

CONCLUSIONS: PN is more often found in patients with CD and/or IBD than in the general population.

Alternate JournalJ Clin Neuromuscul Dis
PubMed ID22538308