Innate lymphoid cells link gut microbes with mucosal T cell immunity.

TitleInnate lymphoid cells link gut microbes with mucosal T cell immunity.
Publication TypeJournal Article
Year of Publication2020
AuthorsCastellanos JG, Longman RS
JournalGut Microbes
Date Published2020
KeywordsAnimals, Antimicrobial Cationic Peptides, Colitis, Cytokines, Gastrointestinal Microbiome, Humans, Immunity, Innate, Immunity, Mucosal, Inflammatory Bowel Diseases, Intestinal Mucosa, Intraepithelial Lymphocytes, OX40 Ligand, Tumor Necrosis Factor Ligand Superfamily Member 15

Despite continuous exposure to trillions of microbes, the intestinal immune system protects the mucosa by balancing barrier protection, tolerance, and immunity. As both sentinel and effector, the mucosal innate immune system plays a central role in coordinating these responses. By integrating signals from the intestinal microbiota, mononuclear phagocytes (MNPs) serve as a critical link in regulating effector functions of group 3 innate lymphoid cells (ILC3s). Our recent work identified the role for MNP production of the IBD-linked protein TNF-like ligand 1A (TL1A) in modulating microbial regulation of ILC3 barrier immunity. These findings highlight a broader role for ILC3s in local control of T cell immunity and their potential role in the pathogenesis and treatment of inflammatory disease.

Alternate JournalGut Microbes
PubMed ID31347946
PubMed Central IDPMC7053954
Grant ListR01 DK114252 / DK / NIDDK NIH HHS / United States
R01 DK120985 / DK / NIDDK NIH HHS / United States
R03 DK111852 / DK / NIDDK NIH HHS / United States
T32 GM007739 / GM / NIGMS NIH HHS / United States