|Title||Inflammatory bowel disease in patients with celiac disease.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Yang A, Chen Y, Scherl E, Neugut AI, Bhagat G, Green PHR|
|Journal||Inflamm Bowel Dis|
|Date Published||2005 Jun|
|Keywords||Adult, Age Factors, Celiac Disease, Cohort Studies, Female, Humans, Inflammatory Bowel Diseases, Male, Middle Aged, Prevalence, Retrospective Studies, Sex Factors|
BACKGROUND: Several case reports and series report an association between celiac disease and inflammatory bowel disease (IBD); however, there is no current data assessing this association. We therefore studied the occurrence of these conditions in a cohort of patients with celiac disease seen at a referral center.
METHODS: A database of patients with celiac disease seen between 1981 and 2002 was analyzed. Only biopsy-proven adults were included. Patients who had endoscopic and pathologic evidence of IBD were identified, and their pathology was reviewed. Age- and sex-adjusted prevalence rate ratios were determined by comparing results with population-based prevalence data.
RESULTS: Among 455 patients with celiac disease, IBD was identified in 10 (5 had ulcerative colitis and 5 had Crohn's disease). This represented an age- and sex-adjusted prevalence rate ratio for ulcerative colitis of 3.56 (95% confidence interval, 1.48-8.56) and for Crohn's disease of 8.49 (95% confidence interval, 3.53-20.42).
CONCLUSION: Within our cohort of patients with celiac disease, IBD was significantly more common than in the general population.
|Alternate Journal||Inflamm. Bowel Dis.|