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Helicobacter pylori is associated with increased risk of serrated colonic polyps: Analysis of serrated polyp risk factors.

TitleHelicobacter pylori is associated with increased risk of serrated colonic polyps: Analysis of serrated polyp risk factors.
Publication TypeJournal Article
Year of Publication2018
AuthorsKumar A, Kim M, Lukin DJ
JournalIndian J Gastroenterol
Volume37
Issue3
Pagination235-242
Date Published2018 May
ISSN0975-0711
KeywordsAdenoma, Age Factors, Aged, Analysis of Variance, Body Mass Index, Colonic Polyps, Colorectal Neoplasms, Continental Population Groups, Female, Gastritis, Helicobacter Infections, Helicobacter pylori, Humans, Male, Middle Aged, Prevalence, Risk Factors, Sex Factors, Smoking
Abstract

BACKGROUND: Sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA) are recognized precursors of colorectal cancer, but their risk factors are not well established. We investigated the association between Helicobacter pylori infection (HPI) and the development of SSA and TSA.

METHODS: Retrospective data were collected on patients aged ≥ 18 years that underwent colonoscopy with biopsy between 2006 and 2016. Based on histology, patients were classified into three groups: those with SSA and/or TSA, (serrated neoplasia group, SN); conventional adenomas only (CA); and with no polyps (NP). Gastric HPI status, demographic, and clinical risk factors were compared between groups using bivariate and multivariable analysis.

RESULTS: HPI was significantly associated with increased risk of SN (SN vs. NP: OR 1.71 [95% CI 1.29-2.27]; SN vs. CA: 1.49 [1.14-1.96]). Additional factors associated with increased risk of SN included the following: age 50-75 years, compared to younger age (SN vs. NP: 2.83 [1.69-4.74]), female gender (SN vs. CA: 1.28 [0.99-1.64]), White race, compared to Blacks (SN vs. CA: 1.52 [1.07-2.15)], overweight and obese body mass index [SN vs. NP: p < 0.001) and current smoking status (SN vs. CA: 2.09 [1.55-2.82)]. Among SN, higher HPI prevalence was associated with dysplasia (p = 0.05) and proximal location (p = 0.01).

CONCLUSIONS: Our data suggest that gastric HPI is associated with increased risk of SN and CA, with a stronger association with SN as compared to CA. Age 50-75 years, female gender, White race, obesity, and smoking were also predictors of SN. A positive correlation of HPI with proximal and dysplastic SN suggests a possible role in serrated pathway carcinogenesis. Prospective studies with large patient population are needed to further investigate this association.

DOI10.1007/s12664-018-0855-8
Alternate JournalIndian J Gastroenterol
PubMed ID29876742