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Bone, inflammation, and inflammatory bowel disease.

TitleBone, inflammation, and inflammatory bowel disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsAgrawal M, Arora S, Li J, Rahmani R, Sun L, Steinlauf AF, Mechanick JI, Zaidi M
JournalCurr Osteoporos Rep
Volume9
Issue4
Pagination251-7
Date Published2011 Dec
ISSN1544-2241
KeywordsCell Communication, Humans, Inflammation, Inflammatory Bowel Diseases, Osteoblasts, Osteoclasts, Osteoporosis, Signal Transduction, Vitamin D Deficiency
Abstract

Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

DOI10.1007/s11914-011-0077-9
Alternate JournalCurr Osteoporos Rep
PubMed ID21935582