The balance of power: innate lymphoid cells in tissue inflammation and repair.

TitleThe balance of power: innate lymphoid cells in tissue inflammation and repair.
Publication TypeJournal Article
Year of Publication2019
AuthorsCastellanos JG, Longman RS
JournalJ Clin Invest
Date Published2019 06 10

Over the last ten years, immunologists have recognized the central importance of an emerging group of innate lymphoid cells (ILCs) in health and disease. Characterization of these cells has provided a molecular definition of ILCs and their tissue-specific functions. Although the lineage-defining transcription factors, cytokine production, and nomenclature parallel those of T helper cells, ILCs do not require adaptive immune programming. Both environmental and host-derived signals shape the function of these evolutionarily ancient cells, which provide pathogen protection and promote tissue restoration. As such, ILCs function as a double-edged sword, balancing the inflammatory and reparative responses that arise during injury and disease. This Review highlights our recent understanding of tissue-resident ILCs and the signals that regulate their contribution to inflammation and tissue repair in health and disease.

Alternate JournalJ. Clin. Invest.
PubMed ID31180335
PubMed Central IDPMC6597213
Grant ListR01 DK114252 / DK / NIDDK NIH HHS / United States
R03 DK111852 / DK / NIDDK NIH HHS / United States
T32 GM007739 / GM / NIGMS NIH HHS / United States