|Title||The balance of power: innate lymphoid cells in tissue inflammation and repair.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Castellanos JG, Longman RS|
|Journal||J Clin Invest|
|Date Published||2019 06 10|
Over the last ten years, immunologists have recognized the central importance of an emerging group of innate lymphoid cells (ILCs) in health and disease. Characterization of these cells has provided a molecular definition of ILCs and their tissue-specific functions. Although the lineage-defining transcription factors, cytokine production, and nomenclature parallel those of T helper cells, ILCs do not require adaptive immune programming. Both environmental and host-derived signals shape the function of these evolutionarily ancient cells, which provide pathogen protection and promote tissue restoration. As such, ILCs function as a double-edged sword, balancing the inflammatory and reparative responses that arise during injury and disease. This Review highlights our recent understanding of tissue-resident ILCs and the signals that regulate their contribution to inflammation and tissue repair in health and disease.
|Alternate Journal||J. Clin. Invest.|
|PubMed Central ID||PMC6597213|
|Grant List||R01 DK114252 / DK / NIDDK NIH HHS / United States |
R03 DK111852 / DK / NIDDK NIH HHS / United States
T32 GM007739 / GM / NIGMS NIH HHS / United States
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